Clinical significance of platelet microparticles in autoimmune thrombocytopenias
JY Wenche, LL Horstman, M Arce… - The Journal of …, 1992 - translationalres.com
Platelet microparticles (PMPs) are vesicles derived from platelet membranes that are too
small (< 0.5 μm) to be detected in routine platelet counting. They arise in association with
platelet activation and other unknown causes. Elevated PMPs have been observed in
idiopathic thrombocytopenic purpura (ITP), a disorder in which autoantibody interacts with
platelets and the opsonized platelets are destroyed by macrophages. However, the clinical
significance of PMP has been unknown. Using flow cytometry, we examined PMP …
small (< 0.5 μm) to be detected in routine platelet counting. They arise in association with
platelet activation and other unknown causes. Elevated PMPs have been observed in
idiopathic thrombocytopenic purpura (ITP), a disorder in which autoantibody interacts with
platelets and the opsonized platelets are destroyed by macrophages. However, the clinical
significance of PMP has been unknown. Using flow cytometry, we examined PMP …