Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life
FHJ Claas, Y Gijbels, J Van Der Velden-De Munck… - Science, 1988 - science.org
FHJ Claas, Y Gijbels, J Van Der Velden-De Munck, JJ Van Rood
Science, 1988•science.orgPatients who have received many transfusions become highly sensitized and develop
antibodies against almost all HLA alloantigens, so that finding a cross-match negative
kidney donor is difficult. A survey of those patients showed that 50 percent did not form
antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical
implications, the data indicate that a human equivalent of murine neonatal or actively
acquired tolerance has now been identified.
antibodies against almost all HLA alloantigens, so that finding a cross-match negative
kidney donor is difficult. A survey of those patients showed that 50 percent did not form
antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical
implications, the data indicate that a human equivalent of murine neonatal or actively
acquired tolerance has now been identified.
Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.
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