Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-a role in pathogenesis and antiproliferative …
PJ Thornalley - General Pharmacology: The Vascular System, 1996 - Elsevier
1. Methylglyoxal is a reactive α-oxoaldehyde and physiological metabolite formed by the
fragmentation of triose-phosphates, and by the metabolism of acetone and aminoacetone. 2.
2. Methylglyoxal modifies guanylate residues to form 6, 7-dihydro-6, 7-dihydroxy-6-methyl-
imidazo [2, 3-b] purine-9 (8) one and N 2-(1-carboxyethyl) guanylate residues and induces
apoptosis. 3. 3. Methylglyoxal modifies arginine residues in proteins to form N δ-(4, 5-
dihydroxy-4-methylimidazolidin-2-yl) ornithine, N δ-(5-hydro-5-methylimidazol-4-on-2-yl) …
fragmentation of triose-phosphates, and by the metabolism of acetone and aminoacetone. 2.
2. Methylglyoxal modifies guanylate residues to form 6, 7-dihydro-6, 7-dihydroxy-6-methyl-
imidazo [2, 3-b] purine-9 (8) one and N 2-(1-carboxyethyl) guanylate residues and induces
apoptosis. 3. 3. Methylglyoxal modifies arginine residues in proteins to form N δ-(4, 5-
dihydroxy-4-methylimidazolidin-2-yl) ornithine, N δ-(5-hydro-5-methylimidazol-4-on-2-yl) …