[HTML][HTML] The Advanced glycation end product, N∊-(Carboxymethyl) lysine, is a product of both lipid peroxidation and glycoxidation reactions (∗)
MX Fu, JR Requena, AJ Jenkins, TJ Lyons… - Journal of Biological …, 1996 - ASBMB
N∊-(Carboxymethyl) lysine (CML) is an advanced glycation end product formed on protein
by combined nonenzymatic glycation and oxidation (glycoxidation) reactions. We now report
that CML is also formed during metal-catalyzed oxidation of polyunsaturated fatty acids in
the presence of protein. During copper-catalyzed oxidation in vitro, the CML content of low
density lipoprotein increased in concert with conjugated dienes but was independent of the
presence of the Amadori compound, fructoselysine, on the protein. CML was also formed in …
by combined nonenzymatic glycation and oxidation (glycoxidation) reactions. We now report
that CML is also formed during metal-catalyzed oxidation of polyunsaturated fatty acids in
the presence of protein. During copper-catalyzed oxidation in vitro, the CML content of low
density lipoprotein increased in concert with conjugated dienes but was independent of the
presence of the Amadori compound, fructoselysine, on the protein. CML was also formed in …