Requirement of MIP-1α for an inflammatory response to viral infection
DN Cook, MA Beck, TM Coffman, SL Kirby, JF Sheridan… - Science, 1995 - science.org
DN Cook, MA Beck, TM Coffman, SL Kirby, JF Sheridan, B Pragnell, O Smithies
Science, 1995•science.orgMacrophage inflammatory protein-1α (MIP-1α) is a chemokine that has pro-inflammatory
and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in
which the gene encoding MIP-1α had been disrupted. Homozygous MIP-1α mutant (-/-) mice
were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice.
Influenza virus-infected-/-mice had reduced pneumonitis and delayed clearance of the virus
compared with infected+/+ mice. The-/-mice had no overt hematopoietic abnormalities …
and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in
which the gene encoding MIP-1α had been disrupted. Homozygous MIP-1α mutant (-/-) mice
were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice.
Influenza virus-infected-/-mice had reduced pneumonitis and delayed clearance of the virus
compared with infected+/+ mice. The-/-mice had no overt hematopoietic abnormalities …
Macrophage inflammatory protein-1α (MIP-1α) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1α had been disrupted. Homozygous MIP-1α mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1α is an important mediator of virus-induced inflammation in vivo.
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