[PDF][PDF] Increased eotaxin-mRNA expression in non-atopic and atopic nasal polyps: comparison to RANTES and MCP-3 expression
J Bartels, S Maune, JE Meyer, R Kulke, C Schlüter… - …, 1997 - researchgate.net
J Bartels, S Maune, JE Meyer, R Kulke, C Schlüter, J Röwert, E Christophers, JM Schröder
Rhinology, 1997•researchgate.netEosinophilic tissue infiltration of nasal mucosa typical for allergic rhinitis and chronic
polypous sinusitis may be due to chemotactic activity of chemokines specific for eosinophils.
The CC-chemokines eotaxin, RANTES and MCP-3 have been postulated to be involved in
the recruitment of eosinophils to certain inflamed tissues. To explore their possible role in
chronic polypous sinusitis we examined eotaxin-, RANTES-and MCP-3-gene expression in
human nasal polyps and normal human nasal mucosa of patients undergoing endonasal …
polypous sinusitis may be due to chemotactic activity of chemokines specific for eosinophils.
The CC-chemokines eotaxin, RANTES and MCP-3 have been postulated to be involved in
the recruitment of eosinophils to certain inflamed tissues. To explore their possible role in
chronic polypous sinusitis we examined eotaxin-, RANTES-and MCP-3-gene expression in
human nasal polyps and normal human nasal mucosa of patients undergoing endonasal …
Summary
Eosinophilic tissue infiltration of nasal mucosa typical for allergic rhinitis and chronic polypous sinusitis may be due to chemotactic activity of chemokines specific for eosinophils. The CC-chemokines eotaxin, RANTES and MCP-3 have been postulated to be involved in the recruitment of eosinophils to certain inflamed tissues. To explore their possible role in chronic polypous sinusitis we examined eotaxin-, RANTES-and MCP-3-gene expression in human nasal polyps and normal human nasal mucosa of patients undergoing endonasal surgery for treatment of chronic polypous sinusitis. Using gene-specific primers in semi-quantitative reverse-transcriptase polymerase-chain-reaction experiments we found elevated expression of eotaxin-and RANTES-mRNA but no MCP-3-mRNA in non-atopic and atopic nasal polyps when compared to normal nasal mucosa.
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