Altered expression of human leukocyte antigen G (HLA‐G) on extravillous trophoblasts in preeclampsia: immunohistological demonstration with anti‐HLA‐G specific …

N Hara, T Fujii, T Yamashita, S Kozuma… - American Journal of …, 1996 - Wiley Online Library
N Hara, T Fujii, T Yamashita, S Kozuma, T Okai, Y Taketani
American Journal of Reproductive Immunology, 1996Wiley Online Library
PROBLEM: Human leukocyte antigen‐G (HLA‐G) is suggested to be at play in the materno‐
fetal immune relationship during pregnancy. In the light of current concept that disruption of
the materno‐fetal immune relationship could account for several complications of
pregnancy, including preeclampsia, we asked whether the expression of HLA‐G protein on
the trophoblasts is altered in preeclampsia. METHOD: The presence of HLA‐G protein in the
extravillous trophoblasts in placenta obtained from five preeclamptic patients and seven …
PROBLEM: Human leukocyte antigen‐G (HLA‐G) is suggested to be at play in the materno‐fetal immune relationship during pregnancy. In the light of current concept that disruption of the materno‐fetal immune relationship could account for several complications of pregnancy, including preeclampsia, we asked whether the expression of HLA‐G protein on the trophoblasts is altered in preeclampsia.
METHOD: The presence of HLA‐G protein in the extravillous trophoblasts in placenta obtained from five preeclamptic patients and seven uncomplicated pregnant women was determined by means of an immunohistochemical technique.
RESULTS: All of the extravillous trophoblasts, which were stained for cytokeratin, were stained for HLA‐G protein in every woman with an uncomplicated pregnancy. In contrast, clusters of extravillous trophoblasts were insularly devoid of the staining for HLA‐G in all the preeclamptic patients.
CONCLUSION: The attenuated expression of HLA‐G protein on the extravillous trophoblasts could be at play in the pathophysiology of preeclampsia.
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