[HTML][HTML] Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells
J Wang, W Han, E Zborowska, J Liang, X Wang… - Journal of Biological …, 1996 - ASBMB
Transforming growth factor β (TGFβ) type I (RI) and type II (RII) receptors are essential for
TGFβ signal transduction. A human colon carcinoma cell line, designated GEO, is marginally
responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells,
which are highly responsive to TGFβ. Hence, the role of RI as a limiting factor for TGFβ
sensitivity and the contribution of low RI levels to the malignant phenotype of GEO cells were
examined. Stable transfection of a tetracycline-regulatable rat RI cDNA increased TGFβ 1 …
TGFβ signal transduction. A human colon carcinoma cell line, designated GEO, is marginally
responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells,
which are highly responsive to TGFβ. Hence, the role of RI as a limiting factor for TGFβ
sensitivity and the contribution of low RI levels to the malignant phenotype of GEO cells were
examined. Stable transfection of a tetracycline-regulatable rat RI cDNA increased TGFβ 1 …