[HTML][HTML] The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes: involvement of Rho kinase
The assembly of contractile proteins into organized sarcomeric units is one of the most
distinctive features of cardiac myocyte hypertrophy. In a well characterized in vitro model
system using cultured neonatal rat ventricular myocytes, a subset of G protein-coupled
receptor agonists has been shown to induce actin-myosin filament organization.
Pretreatment of myocytes with C3 exoenzyme ADP-ribosylated Rho and inhibited the
characteristic α 1-adrenergic receptor agonist-induced myofibrillar organization, suggesting …
distinctive features of cardiac myocyte hypertrophy. In a well characterized in vitro model
system using cultured neonatal rat ventricular myocytes, a subset of G protein-coupled
receptor agonists has been shown to induce actin-myosin filament organization.
Pretreatment of myocytes with C3 exoenzyme ADP-ribosylated Rho and inhibited the
characteristic α 1-adrenergic receptor agonist-induced myofibrillar organization, suggesting …