DNA polymerase, thymidine kinase and DNA synthesis in erythropoletic mouse spleen cells separated on bovine serum albumin gradients
GD Roodman, JJ Hutton, FJ Bollum - … Acta (BBA)-Nucleic Acids and Protein …, 1976 - Elsevier
A single dose of erythropoietin stimulates DNA synthesis in the spleen of the polycythemic
mouse with the maximum effect occurring 48 h after the hormone is administered. The
increase in DNA synthesis is accompanied by morphologic evidence of increased
erythropoiesis and by increases in the activities per cell of both thymidine kinase and
cytoplasmic high molecular weight DNA polymerase-α. The activity of low molecular weight
DNA polymerase-β does not change significantly. Spleen cells from mice which had …
mouse with the maximum effect occurring 48 h after the hormone is administered. The
increase in DNA synthesis is accompanied by morphologic evidence of increased
erythropoiesis and by increases in the activities per cell of both thymidine kinase and
cytoplasmic high molecular weight DNA polymerase-α. The activity of low molecular weight
DNA polymerase-β does not change significantly. Spleen cells from mice which had …