Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase.
M Ezaki, JL Witztum, D Steinberg - Journal of lipid research, 1995 - ASBMB
Oxidative modification of LDL plays an important role in early atherogenesis but the
mechanisms, nonenzymatic and/or enzymatic, by which LDL is oxidized in vivo remain to be
established. Several lines of evidence suggest that cellular 15-lipoxygenase (arachidonate
15-oxidoreductase, EC. 1.13. 11.13)(15-LO) may contribute to oxidative modification of LDL,
including recent studies demonstrating that murine fibroblasts overexpressing 15-LO have
an enhanced capacity to oxidize LDL in the medium. The present studies were undertaken …
mechanisms, nonenzymatic and/or enzymatic, by which LDL is oxidized in vivo remain to be
established. Several lines of evidence suggest that cellular 15-lipoxygenase (arachidonate
15-oxidoreductase, EC. 1.13. 11.13)(15-LO) may contribute to oxidative modification of LDL,
including recent studies demonstrating that murine fibroblasts overexpressing 15-LO have
an enhanced capacity to oxidize LDL in the medium. The present studies were undertaken …