FcεRI on antigen-presenting cells
T Bieber - Current opinion in immunology, 1996 - Elsevier
T Bieber
Current opinion in immunology, 1996•ElsevierThe high-affinity receptor for IgE, FcεRI, expressed on antigen-presenting cells such as
monocytes and Langerhans' cells exhibits profound differences to its homologue expressed
on mast cells and basophils. The lack of the β chain, the presence of an intracellular pool of
preformed α chains, highly variable surface expression, and its function (to provide antigen
focusing for T cells) are some of the main issues which have led us to consider the functional
role of this receptor in a new light.
monocytes and Langerhans' cells exhibits profound differences to its homologue expressed
on mast cells and basophils. The lack of the β chain, the presence of an intracellular pool of
preformed α chains, highly variable surface expression, and its function (to provide antigen
focusing for T cells) are some of the main issues which have led us to consider the functional
role of this receptor in a new light.
The high-affinity receptor for IgE, FcεRI, expressed on antigen-presenting cells such as monocytes and Langerhans' cells exhibits profound differences to its homologue expressed on mast cells and basophils. The lack of the β chain, the presence of an intracellular pool of preformed α chains, highly variable surface expression, and its function (to provide antigen focusing for T cells) are some of the main issues which have led us to consider the functional role of this receptor in a new light.
Elsevier