Physiological role of prostaglandins in the induction of ovulation
A Tsafriri, HR Lindner, U Zor, SA Lamprecht - Prostaglandins, 1972 - Elsevier
The administration of prostaglandin E 2 at the dose levels of 0.7, 1.0 and 1.5 mg/rat on the
afternoon of proestrus to adult rats in which the pre-ovulatory surge of LH was prevented by
Nembutal induced ovum maturation in 58, 70 and 90% and ovulation in 42, 60 and 81% of
the animals, respectively; the incidence of persistent uterine distension was reduced by the
prostaglandin treatment, suggesting that ovarian progesterone secretion was stimulated.
Injection of indomethacin, an inhibitor of prostaglandin synthesis, on its own at 14.30 on the …
afternoon of proestrus to adult rats in which the pre-ovulatory surge of LH was prevented by
Nembutal induced ovum maturation in 58, 70 and 90% and ovulation in 42, 60 and 81% of
the animals, respectively; the incidence of persistent uterine distension was reduced by the
prostaglandin treatment, suggesting that ovarian progesterone secretion was stimulated.
Injection of indomethacin, an inhibitor of prostaglandin synthesis, on its own at 14.30 on the …