Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype
K Nemoto, CC Pilbeam, SR Bilak, LG Raisz - Prostaglandins, 1997 - Elsevier
Prostaglandin E2 (PGE2) is a potent local mediator of cell growth and differentiation in
various tissues. The receptors for PGE2 have been classified into four pharmacological
subtypes, EP1, EP2, EP3, and EP4, based on the responses to selective agonists and
antagonists. We have cloned a functional cDNA for the rat EP2 receptor subtype from a rat
lung cDNA library. The rat EP2 receptor cDNA encodes 357 amino acid residues having
high homology with the human and mouse EP2 receptors and containing seven putative …
various tissues. The receptors for PGE2 have been classified into four pharmacological
subtypes, EP1, EP2, EP3, and EP4, based on the responses to selective agonists and
antagonists. We have cloned a functional cDNA for the rat EP2 receptor subtype from a rat
lung cDNA library. The rat EP2 receptor cDNA encodes 357 amino acid residues having
high homology with the human and mouse EP2 receptors and containing seven putative …