[HTML][HTML] Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor α
B Ren, AP Thelen, JM Peters, FJ Gonzalez… - Journal of Biological …, 1997 - ASBMB
Dietary polyunsaturated fatty acids (PUFA) induce hepatic peroxisomal and microsomal fatty
acid oxidation and suppress lipogenic gene expression. The peroxisome proliferator-
activated receptor α (PPARα) has been implicated as a mediator of fatty acid effects on gene
transcription. This report uses the PPARα-deficient mouse to examine the role of PPARα in
the PUFA regulation of mRNAs encoding hepatic lipogenic (fatty acid synthase (FAS) and
the S14 protein (S14)), microsomal (cytochrome P450 4A2 (CYP4A2)), and peroxisomal …
acid oxidation and suppress lipogenic gene expression. The peroxisome proliferator-
activated receptor α (PPARα) has been implicated as a mediator of fatty acid effects on gene
transcription. This report uses the PPARα-deficient mouse to examine the role of PPARα in
the PUFA regulation of mRNAs encoding hepatic lipogenic (fatty acid synthase (FAS) and
the S14 protein (S14)), microsomal (cytochrome P450 4A2 (CYP4A2)), and peroxisomal …