The role of 15-lipoxygenase in atherogenesis: pro-and antiatherogenic actions
H Kühn, L Chan - Current opinion in lipidology, 1997 - journals.lww.com
H Kühn, L Chan
Current opinion in lipidology, 1997•journals.lww.comOxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been
implicated in this process. Several lines of experimental evidence support such a
proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits
overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the
pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.
implicated in this process. Several lines of experimental evidence support such a
proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits
overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the
pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.
Abstract
Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.
Lippincott Williams & Wilkins