Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
Nature, 1996•nature.com
The human cytomegalovirus genome encodes proteins that trigger destruction of newly
synthesized major histocompatibility complex (MHC) class I molecules. The human
cytomegalovirus gene US 2 specifies a product capable of dislocating MHC class I
molecules from the endoplasmic reticulum to the cytosol and delivering them to the
proteasome. This process involves the Sec6l complex, in what appears to be a reversal of
the reaction by which it translocates nascent chains into the endoplasmic reticulum.
synthesized major histocompatibility complex (MHC) class I molecules. The human
cytomegalovirus gene US 2 specifies a product capable of dislocating MHC class I
molecules from the endoplasmic reticulum to the cytosol and delivering them to the
proteasome. This process involves the Sec6l complex, in what appears to be a reversal of
the reaction by which it translocates nascent chains into the endoplasmic reticulum.
Abstract
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec6l complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
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