The trefoil peptides spasmolytic polypeptide and intestinal trefoil factor are major secretory products of the rat gut
Spasmolytic polypeptide (SP) and intestinal trefoil factor (ITF) are trefoil peptides expressed
by gut mucus cells. Using specific antisera we have quantified and characterized the
molecular forms and distribution of these peptides in the rat gut. SP predominates in the
gastric antrum as a 12 kDa form. ITF (7 kDa) is highly expressed throughout the small
intestine. Both peptides are distributed in the apical secretory compartment of antral mucus
cells (SP) and goblet cells (ITF), and on the lumenal surface. This study quantifies SP and …
by gut mucus cells. Using specific antisera we have quantified and characterized the
molecular forms and distribution of these peptides in the rat gut. SP predominates in the
gastric antrum as a 12 kDa form. ITF (7 kDa) is highly expressed throughout the small
intestine. Both peptides are distributed in the apical secretory compartment of antral mucus
cells (SP) and goblet cells (ITF), and on the lumenal surface. This study quantifies SP and …