A viral mechanism for inhibition of the cellular phosphatase calcineurin
JE Miskin, CC Abrams, LC Goatley, LK Dixon - Science, 1998 - science.org
JE Miskin, CC Abrams, LC Goatley, LK Dixon
Science, 1998•science.orgThe transcription factor NFAT (nuclear factor of activated T cells) controls the expression of
many immunomodulatory proteins. African swine fever virus inhibits proinflammatory
cytokine expression in infected macrophages, and a viral protein A238L was found to
display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-
regulated gene transcription in vivo. This it does by binding the catalytic subunit of
calcineurin and inhibiting calcineurin phosphatase activity.
many immunomodulatory proteins. African swine fever virus inhibits proinflammatory
cytokine expression in infected macrophages, and a viral protein A238L was found to
display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-
regulated gene transcription in vivo. This it does by binding the catalytic subunit of
calcineurin and inhibiting calcineurin phosphatase activity.
The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.
AAAS