Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies
JB Dale, EH Beachey - Infection and immunity, 1984 - Am Soc Microbiol
JB Dale, EH Beachey
Infection and immunity, 1984•Am Soc MicrobiolA set of four monoclonal antibodies was produced against a highly purified pepsin extract of
type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M
proteins from heterologous serotypes and opsonized the respective heterologous
organisms. Our studies suggest that monoclonal antibodies may be useful in identifying
subpeptides of various M proteins containing common, protective epitopes that are capable
of evoking antibodies that would protect against several different potentially" rheumatogenic" …
type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M
proteins from heterologous serotypes and opsonized the respective heterologous
organisms. Our studies suggest that monoclonal antibodies may be useful in identifying
subpeptides of various M proteins containing common, protective epitopes that are capable
of evoking antibodies that would protect against several different potentially" rheumatogenic" …
A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially "rheumatogenic" serotypes.
American Society for Microbiology