[HTML][HTML] Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism
BP Mari, IC Anderson, SE Mari, YY Ning, Y Lutz… - Journal of Biological …, 1998 - ASBMB
Stromelysin-3 (STR-3) is a recently characterized matrix metalloproteinase (MMP) with a
unique pattern of expression and substrate specificity. Unlike other MMPs, STR-3 is
consistently and dramatically overexpressed by multiple epithelial malignancies, including
carcinomas of the breast, lung, colon, head and neck, and skin. Recent studies suggest that
STR-3 promotes the local establishment of epithelial malignancies, contributing to tumor cell
survival and implantation in host tissues; however, STR-3's mechanism of action remains …
unique pattern of expression and substrate specificity. Unlike other MMPs, STR-3 is
consistently and dramatically overexpressed by multiple epithelial malignancies, including
carcinomas of the breast, lung, colon, head and neck, and skin. Recent studies suggest that
STR-3 promotes the local establishment of epithelial malignancies, contributing to tumor cell
survival and implantation in host tissues; however, STR-3's mechanism of action remains …