[HTML][HTML] Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes
TLV Hoek, LB Becker, Z Shao, C Li… - Journal of biological …, 1998 - ASBMB
Reactive oxygen species (ROS) have been proposed to participate in the induction of
cardiac preconditioning. However, their source and mechanism of induction are unclear. We
tested whether brief hypoxia induces preconditioning by augmenting mitochondrial
generation of ROS in chick cardiomyocytes. Cells were preconditioned with 10 min of
hypoxia, followed by 1 h of simulated ischemia and 3 h of reperfusion. Preconditioning
decreased cell death from 47±3% to 14±2%. Return of contraction was observed in 3/3 …
cardiac preconditioning. However, their source and mechanism of induction are unclear. We
tested whether brief hypoxia induces preconditioning by augmenting mitochondrial
generation of ROS in chick cardiomyocytes. Cells were preconditioned with 10 min of
hypoxia, followed by 1 h of simulated ischemia and 3 h of reperfusion. Preconditioning
decreased cell death from 47±3% to 14±2%. Return of contraction was observed in 3/3 …