[HTML][HTML] Expression cloning and characterization of a novel multispecific organic anion transporter
T Sekine, N Watanabe, M Hosoyamada, Y Kanai… - Journal of Biological …, 1997 - ASBMB
Numerous drugs and endogenous compounds are efficiently excreted from the renal
proximal tubule via carrier-mediated pathways. Transepithelial excretion of organic anions
occurs via their accumulative transport from the blood into the proximal tubule cells across
the basolateral membrane and subsequent secretion into the urine through the apical
membrane. Here we report on the isolation of a novel complementary DNA from rat kidney
that encodes a 551-amino acid residue protein (OAT1) with 12 putative membrane-spanning …
proximal tubule via carrier-mediated pathways. Transepithelial excretion of organic anions
occurs via their accumulative transport from the blood into the proximal tubule cells across
the basolateral membrane and subsequent secretion into the urine through the apical
membrane. Here we report on the isolation of a novel complementary DNA from rat kidney
that encodes a 551-amino acid residue protein (OAT1) with 12 putative membrane-spanning …