Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction
U Shu, M Kiniwa, CY Wu, C Maliszewski… - European journal of …, 1995 - Wiley Online Library
U Shu, M Kiniwa, CY Wu, C Maliszewski, N Vezzio, J Hakimi, M Gately, G Delespesse
European journal of immunology, 1995•Wiley Online LibraryPrevious studies on the production of interleukin‐12 (IL‐12) have shown that it is released,
together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a
variety of pathogens. We here report that IL‐12 is also released during the recall response to
soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells
induce the production of IL‐12 by monocytes via a mechanism involving the interaction of T
cell‐associated CD40 ligand with CD40 on monocytes. The data suggest that Ag …
together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a
variety of pathogens. We here report that IL‐12 is also released during the recall response to
soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells
induce the production of IL‐12 by monocytes via a mechanism involving the interaction of T
cell‐associated CD40 ligand with CD40 on monocytes. The data suggest that Ag …
Abstract
Previous studies on the production of interleukin‐12 (IL‐12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL‐12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL‐12 by monocytes via a mechanism involving the interaction of T cell‐associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.
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