Human aortic endothelial cell migration onto stent surfaces under static and flow conditions

EA Sprague, J Luo, JC Palmaz - Journal of vascular and interventional …, 1997 - Elsevier
PURPOSE: The objective of the present study is to establish an in vitro model designed to
quantitatively define human aortic endothelial cell (HAEC) migration onto stainless steel
stent material under both static and flow conditions of high and low wall shear stress.
MATERIALS AND METHODS: To simulate implantation of a stent onto the intact arterial wall,
HAECs were seeded and grown to confluence on thick, firm collagen gels. Flat 1× 1-cm
square, stainless steel pieces were implanted on this endothelialized surface and migration …