[HTML][HTML] Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes: apparent involvement of phosphatidylinositol 3-kinase
P Karnam, ML Standaert, L Galloway… - Journal of Biological …, 1997 - ASBMB
Insulin reportedly (Standaert, ML, Avignon, A., Yamada, K., Bandyopadhyay, G., and Farese,
RV (1996) Biochem. J. 313, 1039-1046) activates phospholipase D (PLD)-dependent
hydrolysis of phosphatidylcholine (PC) in plasma membranes of rat adipocytes by a
mechanism that may involve wortmannin-sensitive phosphatidylinositol (PI) 3-kinase.
Because Rho and ADP ribosylation factor (ARF) activate PC-PLD, we questioned whether
these small G-proteins are regulated by insulin and PI 3-kinase. We found that insulin …
RV (1996) Biochem. J. 313, 1039-1046) activates phospholipase D (PLD)-dependent
hydrolysis of phosphatidylcholine (PC) in plasma membranes of rat adipocytes by a
mechanism that may involve wortmannin-sensitive phosphatidylinositol (PI) 3-kinase.
Because Rho and ADP ribosylation factor (ARF) activate PC-PLD, we questioned whether
these small G-proteins are regulated by insulin and PI 3-kinase. We found that insulin …