Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study
T Thepen, EG Langeveld-Wildschut, IC Bihari… - Journal of Allergy and …, 1996 - Elsevier
In the pathogenesis of atopic dermatitis (AD), IgE plays an important role; and TH2 cells,
producing IL-4, have been ascribed a key role in allergic diseases such as AD. To
investigate the role of TH subpopulations in the onset and continuation of AD, we performed
atopy patch tests (APTs) with house dust mite allergen in patients with AD. Punch biopsy
specimens were taken from the APT site, and sections were immunocytochemically
doublestained for IL-4 and interferon-γ together with different membrane markers. This …
producing IL-4, have been ascribed a key role in allergic diseases such as AD. To
investigate the role of TH subpopulations in the onset and continuation of AD, we performed
atopy patch tests (APTs) with house dust mite allergen in patients with AD. Punch biopsy
specimens were taken from the APT site, and sections were immunocytochemically
doublestained for IL-4 and interferon-γ together with different membrane markers. This …