Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substrates
KE Stremler, DM Stafforini, SM Prescott… - Journal of Biological …, 1991 - ASBMB
Human plasma platelet-activating factor (PAF) acetylhydrolase hydrolyzes the sn-2 acetyl
residue of PAF, but not phospholipids with long chain sn-2 residues. It is associated with low
density lipoprotein (LDL) particles, and is the LDL-associated phospholipase A2 activity that
specifically degrades oxidatively damaged phospholipids (Stremler, KE, Stafforini, DM,
Prescott, SM, Zimmerman, GA, and McIntyre, TM (1989) J. Biol. Chem. 264, 5331-5334). To
identify potential substrates, we synthesized phosphatidylcholines with sn-2 residues from …
residue of PAF, but not phospholipids with long chain sn-2 residues. It is associated with low
density lipoprotein (LDL) particles, and is the LDL-associated phospholipase A2 activity that
specifically degrades oxidatively damaged phospholipids (Stremler, KE, Stafforini, DM,
Prescott, SM, Zimmerman, GA, and McIntyre, TM (1989) J. Biol. Chem. 264, 5331-5334). To
identify potential substrates, we synthesized phosphatidylcholines with sn-2 residues from …