[CITATION][C] Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years
D Daneman, NJ Howard - The Journal of pediatrics, 1980 - Elsevier
D Daneman, NJ Howard
The Journal of pediatrics, 1980•ElsevierRESULTS Presentation. The mean age at diagnosis was 15 days (range 1 to 57 days). In
the two patients diagnosed after one month of age, signs and symptoms of hyperthyroidism
were present soon after birth. There were seven males and two females. A history of
maternal Graves disease was present in all nine. The disease was active during the
pregnancy in five. All children had an alert look, were hyperactive and irritable, and had
tachypnea, tachycardia, and bounding pulses. Eight had prominent eyes, and one had puffy …
the two patients diagnosed after one month of age, signs and symptoms of hyperthyroidism
were present soon after birth. There were seven males and two females. A history of
maternal Graves disease was present in all nine. The disease was active during the
pregnancy in five. All children had an alert look, were hyperactive and irritable, and had
tachypnea, tachycardia, and bounding pulses. Eight had prominent eyes, and one had puffy …
RESULTS
Presentation. The mean age at diagnosis was 15 days (range 1 to 57 days). In the two patients diagnosed after one month of age, signs and symptoms of hyperthyroidism were present soon after birth. There were seven males and two females. A history of maternal Graves disease was present in all nine. The disease was active during the pregnancy in five.
All children had an alert look, were hyperactive and irritable, and had tachypnea, tachycardia, and bounding pulses. Eight had prominent eyes, and one had puffy eyelids. Thyromegaly was found in only five patients. Other common features included prematurity, feeding problems, failure to gain weight, frequent stools, frank congestive cardiac failure, prominent brow and breasts, hepato-and/or splenomegaly, hyperactive reflexes, and fever.
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