[HTML][HTML] Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors
RC Armstrong, T Aja, J Xiang, S Gaur, JF Krebs… - Journal of Biological …, 1996 - ASBMB
The human proto-oncogene bcl-2 and its Caenorhabditis elegans homologue ced-9 inhibit
programmed cell death. In contrast, members of the human interleukin-1β converting
enzyme (ICE) family of cysteine proteases and their C. elegans homologue CED-3 promote
the death program. Genetic experiments in C. elegans have shown that ced-9 is formally a
negative regulator of ced-3 function, but neither those studies nor others have determined
whether CED-9 or Bcl-2 proteins act biochemically upstream or downstream of CED-3/ICE …
programmed cell death. In contrast, members of the human interleukin-1β converting
enzyme (ICE) family of cysteine proteases and their C. elegans homologue CED-3 promote
the death program. Genetic experiments in C. elegans have shown that ced-9 is formally a
negative regulator of ced-3 function, but neither those studies nor others have determined
whether CED-9 or Bcl-2 proteins act biochemically upstream or downstream of CED-3/ICE …