[HTML][HTML] A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation
TE Hebert, S Moffett, JP Morello, TP Loisel… - Journal of Biological …, 1996 - ASBMB
One of the assumptions of the mobile receptor hypothesis as it relates to G protein-coupled
receptors is that the stoichiometry of receptor, G protein, and effector is 1: 1: 1 (Bourne, HR,
Sanders, DA, and McCormick, F.(1990) Nature 348, 125–132). Many studies on the
cooperativity of agonist binding are incompatible with this notion and have suggested that
both G proteins and their associated receptors can be oligomeric. However, a clear physical
demonstration that G protein-coupled receptors can indeed interact as dimers and that such …
receptors is that the stoichiometry of receptor, G protein, and effector is 1: 1: 1 (Bourne, HR,
Sanders, DA, and McCormick, F.(1990) Nature 348, 125–132). Many studies on the
cooperativity of agonist binding are incompatible with this notion and have suggested that
both G proteins and their associated receptors can be oligomeric. However, a clear physical
demonstration that G protein-coupled receptors can indeed interact as dimers and that such …