The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

ML Galisteo, J Chernoff, YC Su, EY Skolnik… - Journal of Biological …, 1996 - ASBMB
Nck is an adaptor protein composed of a single SH2 domain and three SH3 domains. Upon
growth factor stimulation, Nck is recruited to receptor tyrosine kinases via its SH2 domain,
probably initiating one or more signaling cascades. In this report, we show that Nck is bound
in living cells to the serine-threonine kinase Pak1. The association between Nck and Pak1 is
mediated by the second SH3 domain of Nck and a proline-rich sequence in the amino
terminus of Pak1. We also show that Pak1 is recruited by activated epidermal growth factor …