Arthrogryposis multiplex congenita is not a specific disorder but rather a symptom complex
of congenital joint contractures associated with both neurogenic and myopathic disorders.
Pathologic studies, including autopsy evaluation and muscle biopsy alone, were performed
on 74 children with features of arthrogryposis. In 69 children (93%), the deformities were
found to be neurogenic in origin, while five (7%) had myopathic disorders. The children in
these two groups could be subdivided into 17 specific disorders, depending on the site of …