Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

DE Schmechel, AM Saunders… - Proceedings of the …, 1993 - National Acad Sciences
DE Schmechel, AM Saunders, WJ Strittmatter, BJ Crain, CM Hulette, SH Joo…
Proceedings of the National Academy of Sciences, 1993National Acad Sciences
Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a
neuropathological feature of Alzheimer disease (AD). We examined the possibility that
commonly observed variability in A beta deposition in late-onset AD might be related to
apolipoprotein E genotype (APOE gene; the two most common alleles are 3 and 4), since
APOE4 is a susceptibility gene for late-onset AD and apolipoprotein E interacts strongly with
A beta in vitro. In an autopsy series of brains of late-onset AD patients, we found a strong …
Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer disease (AD). We examined the possibility that commonly observed variability in A beta deposition in late-onset AD might be related to apolipoprotein E genotype (APOE gene; the two most common alleles are 3 and 4), since APOE4 is a susceptibility gene for late-onset AD and apolipoprotein E interacts strongly with A beta in vitro. In an autopsy series of brains of late-onset AD patients, we found a strong association of APOE4 allele with increased vascular and plaque A beta deposits. Late-onset AD patients with one or two APOE4 alleles have a distinct neuropathological phenotype compared with patients homozygous for APOE3.
National Acad Sciences