Conjunctival blood flow in sickle-cell disease: Preliminary report

AI FINK, T FUNAHASHI, M ROBINSON… - Archives of …, 1961 - jamanetwork.com
Introduction The development of a sickle-cell crisis remains one of the most interesting and
fundamentally unsolved problems of sicklecell disease. 1, 2 Presumably, the erythrocytes
sickle in the small vessels where the oxygen tension is lower, and one might expect a crisis
to be accompanied by an increase in sickling in the vasculature of various parts of the body.
The crisis is often characterized by episodes of generalized pain associated with fever. No
hematological data exist which can be used to diagnose the presence of such a crisis. One …