[HTML][HTML] Plasma phospholipid transfer protein: adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced …
B Föger, S Santamarina-Fojo, RD Shamburek… - Journal of Biological …, 1997 - ASBMB
In vitro studies have shown that plasma phospholipid transfer protein (PLTP) converts
isolated human high density lipoprotein-3 (HDL 3) into larger HDL particles and generates
lipid-poor apoA-I containing nascent HDL. To evaluate the role of PLTP in vivo we
generated recombinant adenovirus vectors containing either human PLTP cDNA (rPLTP.
AdV) or the reporter luciferase cDNA as a control. After intravenous infusion of 4× 10 7
plaque-forming units (low dose) and 4× 10 8 plaque-forming units (high dose) of rPLTP. AdV …
isolated human high density lipoprotein-3 (HDL 3) into larger HDL particles and generates
lipid-poor apoA-I containing nascent HDL. To evaluate the role of PLTP in vivo we
generated recombinant adenovirus vectors containing either human PLTP cDNA (rPLTP.
AdV) or the reporter luciferase cDNA as a control. After intravenous infusion of 4× 10 7
plaque-forming units (low dose) and 4× 10 8 plaque-forming units (high dose) of rPLTP. AdV …