The metabolic role of lecithin: cholesterol acyltransferase: perspectives from pathology
JA GLOMSET, KR NORUM - Advances in lipid research, 1973 - Elsevier
Publisher Summary This chapter discusses the metabolic role of enzyme lecithin called
cholesterol acyltransferase (LCAT). The role of the LCAT reaction is to prevent unesterified
cholesterol, derived mainly from the surfaces of chylomicrons and very low density
lipoproteins, from accumulating in the plasma. This is successfully accomplished only when
the LCAT reaction balances the mechanisms that increase plasma unesterified cholesterol.
A balance does not occur in familial LCAT deficiency because the enzyme is absent. It does …
cholesterol acyltransferase (LCAT). The role of the LCAT reaction is to prevent unesterified
cholesterol, derived mainly from the surfaces of chylomicrons and very low density
lipoproteins, from accumulating in the plasma. This is successfully accomplished only when
the LCAT reaction balances the mechanisms that increase plasma unesterified cholesterol.
A balance does not occur in familial LCAT deficiency because the enzyme is absent. It does …