[HTML][HTML] Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity
G Romey, B Attali, C Chouabe, I Abitbol… - Journal of Biological …, 1997 - ASBMB
The very slowly activating delayed rectifier K+ channel I Ks is essential for controlling the
repolarization phase of cardiac action potentials and K+ homeostasis in the inner ear. The I
Ks channel is formed via the assembly of two transmembrane proteins, KvLQT1 and MinK.
Mutations in KvLQT1 are associated with a long QT syndrome that causes syncope and
sudden death and also with deafness. Here, we show a new mode of association between
ion channel forming subunits in that the cytoplasmic C-terminal end of MinK interacts directly …
repolarization phase of cardiac action potentials and K+ homeostasis in the inner ear. The I
Ks channel is formed via the assembly of two transmembrane proteins, KvLQT1 and MinK.
Mutations in KvLQT1 are associated with a long QT syndrome that causes syncope and
sudden death and also with deafness. Here, we show a new mode of association between
ion channel forming subunits in that the cytoplasmic C-terminal end of MinK interacts directly …