Platelet responses to thrombin are at least partly mediated by a G-protein-coupled receptor
whose NH 2 terminus is a substrate for thrombin. In the present studies we have examined
the location of thrombin receptors in resting platelets and followed their redistribution during
platelet activation. The results reveal several new aspects of thrombin receptor biology. 1)
On resting platelets, approximately two-thirds of the receptors were located in the plasma
membrane. The remainder were present in the membranes of the surface connecting …