Neurotensin—macrophage interaction: Specific binding and augmentation of phagocytosis
Z Bar-Shavit, S Terry, S Blumberg, R Goldman - Neuropeptides, 1982 - Elsevier
Neurotensin (NT) was found to bind to thioglycollate-elicited mouse peritoneal macrophages
and to modulate their phagocytic capability. A Scatchard analysis of the binding curve of [3
H] NT suggests the presence of two subclasses of binding sites having a.− a KD of 0.9 nM
(4800 sites per cell) and b.− a KD of 28 nM (33500 sites per cell). NT as well as two of its
partial sequences, NT (8–13) and NT (6–13) competed with [3 H] NT for its binding whereas
NT (1–10) was rather ineffective.[3 H] NT was also competitively displaced by tuftsin …
and to modulate their phagocytic capability. A Scatchard analysis of the binding curve of [3
H] NT suggests the presence of two subclasses of binding sites having a.− a KD of 0.9 nM
(4800 sites per cell) and b.− a KD of 28 nM (33500 sites per cell). NT as well as two of its
partial sequences, NT (8–13) and NT (6–13) competed with [3 H] NT for its binding whereas
NT (1–10) was rather ineffective.[3 H] NT was also competitively displaced by tuftsin …