[HTML][HTML] Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes
AR Lloyd, A Biragyn, JA Johnston, DD Taub… - Journal of Biological …, 1995 - ASBMB
Interleukin 8 (IL-8) is a potent chemoattractant and activating factor for human
polymorphonuclear leukocytes (PMN) and hence plays a critical role in the pathogenesis of
acute inflammation. Two unique but homologous receptors for IL-8 have been cloned (IL-
8RA and-B), each of which binds the IL-8 ligand with high affinity. PMN stimulated by
cytokines or lipopolysaccharide (LPS) exhibit changes in IL-8R mRNA and 125 I-IL-8
binding. Granulocyte-colony stimulating factor (G-CSF) treatment of PMN enhances, and …
polymorphonuclear leukocytes (PMN) and hence plays a critical role in the pathogenesis of
acute inflammation. Two unique but homologous receptors for IL-8 have been cloned (IL-
8RA and-B), each of which binds the IL-8 ligand with high affinity. PMN stimulated by
cytokines or lipopolysaccharide (LPS) exhibit changes in IL-8R mRNA and 125 I-IL-8
binding. Granulocyte-colony stimulating factor (G-CSF) treatment of PMN enhances, and …