The CCR5 deletion mutation fails to protect against multiple sclerosis
BH Bennetts, SM Teutsch, MM Buhler, RNS Heard… - Human immunology, 1997 - Elsevier
Recent advances in the understanding and identification of chemokines and their receptors
have provided evidence for their consideration as candidate loci with respect to genetic
susceptibility/resistance to MS. Increased levels of the chemokine, macrophage
inflammatory protein (MIP)-1α, have been demonstrated in the cerebrospinal fluid of both
patients with MS and mice with EAE, and anti-MIP-1α antibodies have been shown to
prevent EAE. Recently, a common deletion mutation in the gene for the major receptor for …
have provided evidence for their consideration as candidate loci with respect to genetic
susceptibility/resistance to MS. Increased levels of the chemokine, macrophage
inflammatory protein (MIP)-1α, have been demonstrated in the cerebrospinal fluid of both
patients with MS and mice with EAE, and anti-MIP-1α antibodies have been shown to
prevent EAE. Recently, a common deletion mutation in the gene for the major receptor for …