Based on previous observations showing that inflammatory episodes in the central nervous
system (CNS) of SJL/J mice with adoptively transferred experimental allergic
encephalomyelitis (EAE) are associated with a concomitant upregulation of adhesion-
related molecules around CNS blood vessels, the present study was undertaken to block the
development of EAE with injections of monoclonal antibodies (mAbs) to two different
adhesion molecules. The mAbs selected were directed against intercellular adhesion …