Recent developments in multiple sclerosis research have highlighted the necessity to
reevaluate the structural pathology and immunopathology of multiple sclerosis. The Ž.
advent of magnetic resonance MR imaging for disease monitoring has lead to new insights
into the natural history of multiple sclerosis and the dynamics of the development of brain
lesions. At present, however, the structural correlates of the variety of MR images are far
from clear. Furthermore, the heterogeneity of MR lesions within and among different patients …