Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions
JE Simpson, J Newcombe, ML Cuzner… - Journal of …, 1998 - Elsevier
β-chemokines induce the directional migration of monocytes and T lymphocytes and are
thus associated with chronic inflammation. Using immunocytochemistry and in situ
hybridisation (ISH) techniques, we have examined the expression of the β-chemokines
monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α,
MIP-1β, and RANTES (regulated upon activation, normal T cell expressed and secreted) in
post-mortem human brain from multiple sclerosis (MS) cases, at different stages of lesion …
thus associated with chronic inflammation. Using immunocytochemistry and in situ
hybridisation (ISH) techniques, we have examined the expression of the β-chemokines
monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α,
MIP-1β, and RANTES (regulated upon activation, normal T cell expressed and secreted) in
post-mortem human brain from multiple sclerosis (MS) cases, at different stages of lesion …