Inflammatory cell recruitment to the central nervous system (CNS) is a cardinal feature of
physiological and pathological processes, including multiple sclerosis (MS). Despite recent
progress, the soluble signals that attract inflammatory cells from the vascular compartment
into the CNS parenchyma remain obscure. We favor the hypothesis that chemoattractant
cytokines termed 'chemokines' are uniquely important for mediating leukocyte entry into
CNS tissues during immunemediated inflammation. Three lines of evidence supporting this …