Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
G Zurawski, JE de Vries - Immunology today, 1994 - Elsevier
Abstract Interleukin 13 (IL-13) is a recently described protein secreted by activated T cells
which is a potent in vitro modulator of human monocyte and B-cell functions. The data,
reviewed here by Gerard Zurawski and Jan de Vries, shows that IL-13 shares biological
activities with IL-4, their genes are closely linked in both the human and mouse genomes,
and there is sequence homology between IL-13 and IL-4 proteins. Although the cloned IL-4
receptor protein (IL-4R) does not bind IL-13, it appears that the functional IL-4R and IL-13R …
which is a potent in vitro modulator of human monocyte and B-cell functions. The data,
reviewed here by Gerard Zurawski and Jan de Vries, shows that IL-13 shares biological
activities with IL-4, their genes are closely linked in both the human and mouse genomes,
and there is sequence homology between IL-13 and IL-4 proteins. Although the cloned IL-4
receptor protein (IL-4R) does not bind IL-13, it appears that the functional IL-4R and IL-13R …