Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in …

D Robinson, Q Hamid, A Bentley, S Ying… - Journal of Allergy and …, 1993 - Elsevier
Background: We have examined whether the local eosinophilia provoked by inhalational
allergen challenge of patients with atopic asthma is associated with the appearance, in vivo,
of activated T H2-type T helper lymphocytes. Methods: Fifteen patients with atopic asthma
had bronchial wash and bronchoalveolar lavage (BAL) 24 hours after allergen or diluent
challenge separated by at least 21 days. Results: There was an increase in eosinophils in
both bronchial wash (p= 0.01) and BAL (p= 0.02) after allergen challenge but not after …