[HTML][HTML] The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
AS Fanning, BJ Jameson, LA Jesaitis… - Journal of biological …, 1998 - ASBMB
The tight junction protein ZO-1 belongs to a family of multidomain proteins known as the
membrane-associated guanylate kinase homologs (MAGUKs). ZO-1 has been
demonstrated to interact with the transmembrane protein occludin, a second tight junction-
specific MAGUK, ZO-2, and F-actin, although the nature and functional significance of these
interactions is poorly understood. To further elucidate the role of ZO-1 within the epithelial
tight junction, we have introduced epitope-tagged fragments of ZO-1 into cultured MDCK …
membrane-associated guanylate kinase homologs (MAGUKs). ZO-1 has been
demonstrated to interact with the transmembrane protein occludin, a second tight junction-
specific MAGUK, ZO-2, and F-actin, although the nature and functional significance of these
interactions is poorly understood. To further elucidate the role of ZO-1 within the epithelial
tight junction, we have introduced epitope-tagged fragments of ZO-1 into cultured MDCK …