[HTML][HTML] An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton

DB Short, KW Trotter, D Reczek, SM Kreda… - Journal of Biological …, 1998 - ASBMB
The function of the cystic fibrosis transmembrane conductance regulator (CFTR) as a Cl−
channel in the apical membrane of epithelial cells is extensively documented. However, less
is known about the molecular determinants of CFTR residence in the apical membrane,
basal regulation of its Cl− channel activity, and its reported effects on the function of other
transporters. These aspects of CFTR function likely require specific interactions between
CFTR and unknown proteins in the apical compartment of epithelial cells. Here we report …